Non-catalytic functions of DNMT1
نویسندگان
چکیده
منابع مشابه
Non-catalytic functions of DNMT1.
Mammalian DNA methyltransferase 1 (DNMT1) is essential during early embryo development. Consistent with its key role in embryogenesis, depletion of this protein in adult somatic cells promotes severe cellular dysfunctions and cell death. DNMT1 contains a highly evolutionary conserved C-terminal catalytic DNA methyltransferase domain that is thought to be the responsible for the maintenance of C...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2012
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.7.2.18756